The article by Academician P. L. Kapitsa published below is devoted to problems of the utmost importance, which have come to be termed "global." The Twenty - fifth Congress of the CPSU pointed to the need to study them scientifically and solve them practically, emphasizing that they touch on the interests of humanity as a whole and will exercise an increasingly marked influence on the lives of every people and on the entire system of international relations. In their social philosophical (...) aspects they have been discussed more than once in the pages of Voprosy filosofii. Discussions of these problems took place at the round tables entitled "Man and His Environment" [See translation in our Fall-Winter 1974 number. — Ed., Soviet Studies in Philosophy], "Social Philosophy Problems of Demography," and "Science and Global Problems of Our Time," and numerous articles have been published in such series as "Science and Social Progress," "The Peace Program and the Dialectics of International Relations" [See translation in our Fall 1975 issue. — Ed., Soviet Studies in Philosophy], and "Man — Society — Nature." The editors of the journal, guided by the directives of the Twenty-fifth Party Congress on the need for further investigation of such global problems of our time, are inclined to continue the discussion of them in the future; another round table devoted to these problems is being planned now. The article by Academician P. L. Kapitsa, it seems to us, will provide fruitful stimuli for discussion at this round table, which will probably be published in several installments. As the author himself emphasizes, certain positions in his article are debatable and require discussion. The journal invites philosophers, demographers, economists, and representatives of the natural sciences to take part in discussions of the problems posed. Certain questions examined in Kapitsa's article are also treated in articles by Howard L. Parsons, A. D. Ado, and Iu. A. Kirshin published in this issue of the journal. (shrink)

The heme‐containing cytochromes P‐450 are a ubiquitous family of monooxygenase isozymes responsible for the oxidative metabolism of a wide variety of endogenous as well as exogenous compounds. Many of the compounds metabolized by this enzyme system are effectively detoxified and converted to derivatives more easily eliminated from the organism. However, some compounds can be activated to reactive species capable of eliciting a cascade of toxic lesions, including cancer. Since its discovery nearly 30 years ago, the cytochrome P‐450 enzyme system has (...) received a great deal of attention, particularly in the areas of their mechanisms of metabolism, range of substrate specificity, the purification and characterization of the multiple isozymes and, more recently, the regulation of expression of specific forms. This review will discuss current notions concerning the expression of at least one cytochrome P‐450 isozyme and future directions that should lead to a more complete understanding of cytochrome P‐450 gene expression in general, particularly as it impacts upon biochemical pharmacology. (shrink)

This book examines the relationship between law and scientific advancement, with a particular focus on the theory of evolution and medical innovation. Historically, the law has struggled to keep pace with modern medical advances. The authors demonstrate that the laws that govern human behaviour must evolve in response to such advances."--Provided by publisher.

I should like to begin by removing a misconception to which the title of this lecture may possibly give rise. My concern is not with general propositions regarding certain fairly well-attested human characteristics of the kind to which historians may, from time to time, advert in the course of their work or to which they may appeal in support of the account provided of some particular event or occurrence. I am not myself an historian, and for me to make ex (...) cathedra pronouncements on such topics as these might well seem to constitute an unjustifiable intrusion upon a field about which I am not qualified professionally to speak. My subject lies within the sphere of philosophy of history rather than of history proper; it belongs, in other words, to a branch of philosophical inquiry, and as such relates, not to empirical facts and events of the sort to which the practising historian addresses himself, but to those assumptions, categories and modes of procedure that are, or are believed to be, intrinsic to historical thought and discourse. In this general context I wish to discuss two approaches to the problem of elucidating the character of historical knowledge and explanation. Both of the approaches I have in mind have achieved a considerable measure of support at the present time; they have also been widely understood as offering profoundly divergent — indeed, diametrically opposed — views of what is central to the structure of historical thinking and to the type of activity upon which the historian is essentially engaged. It has on occasions been suggested that what — amongst other things — divides adherents to the views in question is the fact that they are committed to radically different conceptions of the subject-matter of the historical studies; that is to say, of human beings and their activities. In the light of this fundamental disagreement, it is argued, many of the more intractable controversies that have arisen concerning the concepts and interpretative schemes in terms of which it is possible or legitimate to treat the human past become readily intelligible. In what follows I want to examine this claim. First, however, let me give a brief, and necessarily somewhat crude, outline of the two positions I have referred to, starting with one that is often described as ‘positivist’. (shrink)

Note by the Editor of Voprosy filosofii: The presidium of the USSR Academy of Sciences has decided to hold, in Moscow in December 1980, the Third USSR Conference on Philosophical Problems of Contemporary Natural Science, dedicated to the one hundred and tenth anniversary of the birth of V. I. Lenin, and has established an organizing committee headed by P. N. Fedoseev, vice-president of the Academy, to prepare and conduct the conference.

Although Thomas Aquinas assumes that all knowledge begins in the senses, he maintains that substantial forms and the essences of material things are not apparent to the senses. Clearly, the noetic of abstraction per se cannot account for our knowledge of them. Thomas often says that they are “unknown in themselves” but “become known” through their accidents. The author argues that properties, or proper accidents — namely, accidents that are interconvertible with a subject — play a crucial role in this (...) obscure area of Thomas’s thought. Beginning with an examination of the property in logic , the author goes on to examine Thomas’s accounts of heat as a property of fire, and the powers of the soul as properties of its essence. Thomas maintains that such properties flow from the essence by a causal relation that he calls resultatio, but that their coexistence with the essence is absolutely necessary in a quasi-logical manner . Finally, the author suggests that in Thomas’s view, accidents really do make the hidden quiddities of their subjects known: knowing created things through their accidents is not at all like knowing God through creatures. (shrink)